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https://doi.org/10.14300/mnnc.2017.12081

Interrelation of endothelial nitric oxides synthase activity in tissues of the stomach and magnesium balance in the period of erosive-ulcerative acid-induced lesion development in rats with different resistance to stress

[Experimental medicine]
Lyudmila Rogova; Victoria Povetkina;

Acetate stomach ulcer was experimentally modeled in stress resistant and stress nonresistant rats for immunohistochemical identifying a specific number and expression intensity of eNOS-positive cells and determination of the magnesium level in biological media. The content of intra-erythrocyte magnesium in reaction with titanium yellow was reduced in rats with different resistance to stress in low eNOS activity in the gastric mucosa, in the muscular layer in stress nonresistant animals and almost complete absence of antigen-positive cells in the submucosa. A positive correlation was found between the level of intra-erythrocyte magnesium and the specific number of eNOS-positive cells in the gastric mucosa in both groups of animals and also between expression intensity in the submucosa of stress nonresistant rats. A relationship was established between the magnesium content, specific number and expression intensity of eNOS in stress nonresistant rats in the stomach submucosa.

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Keywords: endothelial nitric oxide synthase, magnesium, acetate ulcer, stress resistant, stress nonresistant rats