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Erythropoetin and proinflammatory cytokines production against the undifferentiated dysplasia of the connecting tissue at congenital developmental anomalies of urinary system organs at children

[Original research] [Pediatrics]
Aneta Mambetova; Rashid Zhetishev; Nina Shabalova;

The estimation of influence of severity level of nondifferentiated dysplasia of a connective tissue (NDCT) on erythropoietin (EPO) production, the tumour necrosis factor-α (the TNF-α) and interleukine-1β (IL-1β) at congenital defects of organs of urinary system in children with a vesicoureteral reflux, hydronephrosis and ureterohydronephrosis of a congenital genesis was carried out. It was shown that the majority of children (73,5%) with congenital defects had average and serious severity levels of NDCT.

It is established that authentically higher concentration of INF-α and IL-1β and lower EPO associated with more serious severity level of NDCT. Negative correlation connections of EPO with both cytokines were revealed at patients with moderate/serious severity levels of NDCT. NDCT severity level at an obstructive syndrome (vesicoureteral reflux, hydronephrosis and ureterohydronephrosis) is responsible for high concentrations of INF-α and IL-1β. The hyperproduction of INF-α and IL-1β is responsible for low concentration of EPO.

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Keywords: INF-α, IL-1β, erythropoetin, nondifferentiated dysplasia of a connecting tissue