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[Abstracts]
Natalya Geyvandova; Andrey Lipov; Sofia Rogova;
107 patients with chronic viral hepatitis C (CVHC) were examined. The polymorphism of the IL-28B gene rs12979860 and the content of IL-28B in the blood have been studied. With CVHC more often than in a healthy population, there is the genotype T/T IL-28B and, more rarely, the C/C genotype. The low blood level of IL-29 in CVHC was associated with the genotype T/T IL-28B. Decreased production of IL-29 may be one of the factors contributing to the chronization of HCV infection.
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Keywords: chronic viral hepatitis C, interferons, interleukins, prognosis