Site search
Correspondence address
310 Mira Street, Stavropol, Russia, 355017
Tel
+7 865 2352511, +7 865 2353229.
E-mail
medvestnik@stgmu.ru
The journal is included into The list of leading scientific periodicals.
The journal is included into VINITI database and is registered in Electronic scientific library.
The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.
[Experimental medicine]
Natalia Bykova; Arkadiy Odolsky; Victoria Grigoryan;
The article deals with the problems of experimental modeling and the treatment of inflammatory and inflammatorydegenerative diseases of periodontal tissues. Experiments were performed on 130 white Wistar rats. It is established that the violation of prooxidant-antioxidant homeostasis in experimental periodontitis is manifested in the activation of processes of lipid peroxidation and decreased activity of antioxidant enzymes in the blood serum and homogenates of periodontal tissues. The use of the drug combination of glucosamine hydrochloride and chondroitin sulfate reduces the generation of free radicals and leads to normalization of prooxidant-antioxidant homeostasis, which confirms the feasibility of their use in pathogenetic therapy of inflammatory diseases of periodontal tissues.
References:
1. Arutyunov A. V., Sirak S. V., Shchetinin E. V., Bykova N. I. Endodontiya Today. – Endodontics Today. 2015;1:15-18.
2. Kompancev D. V. Medline.ru. 2012;13(3):791-802.
3. Sirak S. V., Zeker’jaeva M. V. Parodontologiya. – Parodontology. 2010;15(1):46-50.
4. Sirak S. V., Shapovalova I. A., Afanas’eva O. V. Medicinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2007;8(4):33-36.
5. Jordan K. M., Arden N. K., Doherty M., Bannwarth B., Bijlsma J. W. J. Annals of the Rheumatic Diseases. 2003;62(12):1145-1155. doi: 10.1136/ard.2003.01174
6. Lauder R. M. Complementary Therapies in Medicine. 2009;17(1):56-62. doi: 10.1016/j.ctim.2008.08.004
7. McAlindon T. E., La Valley M. P., Gulin J. P., Felson D. T. Journal of the American Medical Association. 2000;283(11):1469-1475.
8. Mero A., Campisi M. Polymers. 2014;6(1):346-369. doi: 10.3390/polym6020346
9. Sakai S., Sugawara T., Kishi T., Yanagimoto K., Hirata T. Life Sciences. 2010;86(9-10):337-343. doi: 10.1016/j.lfs.2010.01.001
10. Silbert J. E., Sugumaran G. IUBMB Life. 2002;54(4):177-186. doi: 10.1080/15216540214923
11. Sirak S. V., Entschladen F., Shchetinin E. V., Grimm W. D. Journal of Clinical Periodontology. 2015;42(S17):328a-328.
12. Sterzi S., Giordani L., Morrone M., Lena E., Magrone G. European Journal of Physical and Rehabilitation Medicine. 2016;52(3):321-330.
Keywords: inflammation, regeneration, periodontium, glucosamine, chondroitin