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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Assesment of the action of melatonin and fluoxetine on the model of resinpina depression

[Clinical Pharmacology] [Pharmacology]
Olga Kaminskaya; Eduard Beyer; Eduard Arushanyan;

Pineal hormone melatonin (0.5 mg/kg), fluoxetine (5 mg/kg) and their combination were studies on model of reserpine-induced depression in rats. Experiments were performed in the «open field» test, reserpine-induced ptosis and hypothermia. As was shown melatonin, less than fluoxetine, could antagonize reserpine-induced depression. In combination with fluoxetinemelatonin potent it antidepressant-like effects.

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Keywords: reserpine depression, melatonin, fluoxetine, combination


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