logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru.

Study of chemical composition of peptides as а part of niosomal drug «Regenerin»

[Clinical Pharmacology] [Pharmacology]
Igor Bazikov; Alexandr Kulichenko; Dmitriy Kovalev; Viktoria Binatova; Alexander Maltsev; Natalia Kalinkina; Ekaterina Goptareva; Violeta Korolkova;

The peptide composition of the drug «Regenerin» on the basis of animal placenta extracts was studied by mass spectrometry. It was shown that the obtained mass spectra include signals of different intensities in the range 2000– 10 500 Da. Characteristic features of a number of isolated peptides has been described. The peptides of molecular weight 1000–10 000 Da were represented by cytomedins, which play an important role in maintaining the structural homeostasis of cell populations. These substances have the ability to regulate the functional activity of the cell populations, which explains the regenerative ability of the drug in chemical burns.

Download

References:
1. Bazikov I. A., Lukinova V. V., Malinin N. I, Maltsev A. N. Evrazysky soyuz uchenykh (ESU). – Eurasian Union of Scientists (ESU). 2016;3(24.):40-42.
2. Bazikov I. A., Malinin N. I., Maltsev A. N., Aytekova S. R., Lukinova V. V. Problemy meditsinskoy mikologii. – Problems of medical mycology. 2016;2(18):41.
3. Bazikov I. A., Sumkin O. B., Botasheva V. S., Klimanovich I. V., Penkov N. I., Chekrygin E. V., Ghukasyan A. L., Deryazhentseva M. A., Kalinkin N. I., Bazikov F. I. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2013;8(4):9-13.
4. Bazikov I. A., Sumkina O. B., Botasheva V. S., Klimanovich I. V., Penkova N. I., Chekrygina Ye. V., Domenyuk D. A. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2014;9(4):336-340.
5. Gromova O. A., Torshin I. Yu., Volkov A. Yu., Nazarenko O. A., Smarygin A. V. Plasticheskaya khirurgiya i kosmetologiya. – Plastic surgery and cosmetology. 2010;4:512-687.
6. Morozov V. G., Havinson V. H. Peptidnye bioregulyatory (25-letny opyt eksperimentalnogo i klinicheskogo izucheniya). SPb.: «Nauka». 1996.
7. Torshin I., Volkov A., Gilels A., Esteticheskaya meditsina. – Aesthetic Medicine. 2013;12(1):33-45.
8. Yakovlev G. M., Morozov V. G., Havinson V. H. Citomediny. Funciya v organizme. Ispolzovanie v klinicheskoj practike. Sb. nauch.tr. Tomsk, 1986.
9. Beyssac I., Martini M. C., Cotte J. International Journal of Cosmetic Science. 1986;8(4):175-188.
10. Boeckmann B., Bairoch A., Apweiler R. Nucleic Acids Research. 2003;31(1): 365-370.
11. Julliard J. H., Shibasaki T., Ling N., Guillemin R. G. Science. 1980;208:183-185.
12. Leinoa O., Kiviranta H., Karjalainen A. K., Kronberg-Kippilä C., Sinkko H., Larsen Erik H., Virtanen S., Tuomisto J. T. Food and Chemical Toxicology. 2013;54:59-69.
13. Peyman A., Gabriel C., Benedickter H. R., Fröhlich J. Physics in Medicine and Biology. 2011;56(7):93.
14. Sastry B. V., Barnwell S. L., Tayeb O. S. Placenta. Supplement. 1981;3:337.
15. Sakura H., Aoki S., Ozawa T. Acta Endocrinol. 1991;125(5):454-458.

Keywords: «Regenerin» placenta extract, cytomedines, wound healing


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy