logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru.

Cytokines in large intestine mucosa and intestinal microbiota in patients with chronic pancreatitis

[Internal diseases]
Anna Bykova; Irina Kozlova;

The clinical and morphological features of the colon, concentration of cytokines large intestine mucosa and intestinal microbiota in patients with chronic pancreatitis were studied. The objects were 113 patients with chronic pancreatitis. The frequency of intestinal dysfunction, endoscopic and morphological changes in the colon mucosa and concentration of interleukin-2, interleukin-6 and interleukin-8 in the colon biopsy specimens were analysed. Chronic pancreatitis was associated with the functional and structural changes of the colon. The content of pro-inflammatory cytokines in the colon mucosa was increased.

Download

References:
1. Bordin D. S. Jeksperimental’naja i klinicheskaja gastrojenterologija. – Experimental and clinical gastroenterology. 2011;7:122-129.
2. Bykova A. P., Kozlova I. V. Jeksperimental’naja i klinicheskaja gastrojenterologija. – Experimental and clinical gastroenterology. 2016;11:69-75.
3. Gubergric N. B., Lukashevich G. M., Golubova O. A., Fomenko P. G. Jeksperimental’naja i klinicheskaja gastrojenterologija. – Experimental and clinical gastroenterology. 2010;8:27-34.
4. Ivashkin V. T., Maev I. V., Ohlobystin A. V., Kucherjavyj Ju. A., Truhmanov A. S., Sheptulin A. A., Shifrin O. S., Lapina T. L., Osipenko M. F., Simanenkov V. I., Hlynov I. B., Alekseenko S. A., Alekseeva O. P., Chikunova M. V. Rossijskij zhurnal gastrojenterologii, gepatologii, koloproktologii. – Russian magazine of gastroenterology, Hepatology, Coloproctology. 2014;4:70-97.
5. Kozlova I. V., Pahomova A. L. Jeksperimental’naja i klinicheskaja gastrojenterologija. – Experimental and clinical gastroenterology. 2015;6:4-10.
6. Mingazova S. K., Hasanova A. R., Nigmatullina A. Je., Musin A. G., Mutalova Je. G., Mingazetdinova L. N. Medicinskij vestnik Bashkortostana. – Medical journal of Bashkortostan. 2012;6:49-52.
7. Rusin V. I., Sirchak E. S., Filip S. S., Servetnik P. F. Hirurgija. Vostochnaja Evropa. – Surgery. Eastern Europe. 2016;4:545-552.
8. Sabel’nikova E. A. Jeksperimental’naja i klinicheskaja gastrojenterologija. – Experimental and clinical gastroenterology. 2011;3:111-116.
9. Siraeva A. S., Faizova L. P. Jeksperimental’naja i klinicheskaja gastrojenterologija. – Experimental and clinical gastroenterology. 2014;5:21-26.
10. Blaser M. J. J. Clin. Invest. 2014;10:4162-4165.
11. Etemad B., Whitcomb D. C. Gastroenterology. 2001;120(3):682-707.
12. Hoffmeister A., Mayerle J., Beglinger C., Büchler M. W., Bufler P., Dathe K., Friess H., Fölsch U., Izbicki J., Kahl S., Klar E., Keller J., Knoefel W. T., Layer P., Löhr M., Meier R., Riemann J. F., Rünzi M., Schmid R. M., Schreyer A., Tribl B., Werner J., Witt H., Mössner J., Lerch M. M. AWMF-online 2012:115. Available at: https://www.hindawi. com/journals/jdr/2015/284680/
13. Leal-Lopes C., Velloso F. J., Campopiano J. C., Sogayar M. C., Correa R. G. Journal of Diabetes Research. 2015:20. Available at: https://www.hindawi.com/journals/ jdr/2015/284680/
14. Mattar R., Lima G. A., da Costa M. Z., Silva-Etto J. M., Guarita D., Carrilho F. J. Arquivos Gastroenterol. 2014;51(4):297- 301. doi: 10.1590/S0004-28032014000400006
15. Raghuwansh P. S., Rajinder K. D., Ashok K. S. Curr. Opin. Gastroenterol. 2013;29(5):523-530. doi: 10.1097/ MOG.0b013e328363e399
16. Sarner M., Cotton P. B. Gut. 1984;25:756-759. 17. Yadav D., Lowenfels A. B. Gastroenterol. 2013;144(6):1252-1261. doi: 10.1053/j.gastro.2013. 01.068

Keywords: chronic pancreatitis, colon mucosa, biopsy, pro-inflammatory cytokines, colon microbiome


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy