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https://doi.org/10.14300/mnnc.2017.12041

Relationship between tumor necrosis factor alpha gene polymorphism and development of purulent septic complications of severe acute pancreatitis

[Original research]
Ildar Lutfarakhmanov; Petr Mironov; Alexey Tikhonov;

The aim of study was to evaluate the relationship of tumor necrosis factor alpha gene polymorphism with the development of abdominal sepsis in patients with severe acute pancreatitis (SAP). The study included 100 patients (39 women and 61 men, mean age 48.1±14.2 years). Patients were divided into two groups: patients with proven abdominal sepsis (AS) (n=49) and patients with unproven AS (controls, n=51). The genotype of –308 TNF-α polymorphism was determined in 89 patients: 49 patients with TOP and proven AS and 40 patients with TOP and unproven AS. There were no statistically significant differences in age, sex, concomitant diseases, severity of the condition and outcomes among the carriers of AG and GG genotypes of –308 TNF-α polymorphism in patients with AS. Among carriers of AG genotype we revealed more frequent development of purulent septic complications, and these patients were more often at risk of developing other than the abdominal cavity foci of infection compared with carriers of the GG genotype of the –308 TNF-α polymorphism.

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Keywords: acute pancreatitis, sepsis, TNF-α, gene polymorphism