• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2016.11088

The state of cellular immunity in patients with chronic obstructive pulmonary disease, combined with osteoarthritis

[Internal diseases]
Tatyana Skiba;

The combination of COPD and osteoarthritis (OA) is quite common in clinical practice, reducing opportunities for physical rehabilitation of the patient. The systemic inflammation in each of comorbid diseases defines the status of the immune system, in particular its cellular link. In order to study cell immunity of patients with COPD concomitant with OA we examined 54 patients with exacerbation of COPD of a clinical group B – GOLD II, in the middle ages (54,4 ± 3,1) years and period of the disease (9,6 ± 1,1) years. Of these, patients with acute exacerbation of COPD, comorbid with OA in the phase of unstable remission were 33 people – the main group, with COPD without OA comorbidity – 21 patients (comparison group). The control group included 25 healthy persons of the same sex and age. In all surveyed, in addition to routine clinical and instrumental parameters, T-, B-lymphocytes, T-helpers/inductors (Th), T suppressor/ killers in the test with monoclonal antibodies classes of CD3+, CD4+, CD8+ and CD22+ were determined. In patients with acute exacerbation of COPD, comorbid with OA, the decreased number of T-lymphocytes with phenotype CD3+ in absolute terms by 1.7 times (p<0.05) in the relative – in 1,3 times (p<0.05), fewer T-lymphocyte helpers in 1,7 and 1,4 times (p<0.05) were noted, respectively, while maintaining constant rates of T-lymphocytes with the phenotype CD8+. The indicators of cellular immunity in patients with COPD without comorbidity were also decreased but less significantly. Between the levels of CD3+-, CD4+-cells and FEV1 of the patients of the main group, as well as between CD3+-cells and FEV1 of the patients in the comparison group positive correlation dependences were revealed, and negative correlation was revealed between the amount of CD3+-lymphocytes and the level of pain in patients of the main group according to pain scale, indicating a negative effect of OA on clinical presentation of COPD.

Download

References:
1. Avdeev S. N. Pulmonologiya. – Pulmonology. 2007;2:104-112.
2. Nasonova V. A. Consilium Medicum. 2009;1(2):43–48.
3. Rekalova O. M.,Panasyukova O. R., Chernushenko K. F., Matvienko Ju. O. Astma ta alergiya. – Asthma and allergy. 2015;3:40-46.
4. Yashina L. O., Gumenuk M. I., Ignatieva V. I., Gumenuk G. L. Astma ta alergiya. – Asthma and allergy. 2013;2:35-41.
5. Skripnik L. M. Arhiv klinichnoi medicini. – Archive of clinical medicine. 2013;1(19):82-84.
6. Feschenko Ju. I. Zdorovya Ukraini. – The Health of Ukraine. 2013;17(318):45-46.
7. Cherniayev A. L. Consilium Medicum. Ukraina. 2011;5(1):9-14.
8. Chuchalin A. G. Zdorovya Ukraini. – The Health of Ukraine. 2010;2(231):26-27.
9. Barnes P. J. Nat. Immunol. Rev. 2008;8:183-192.
10. Bonnet C. S., Walsh D. A. Rheumatology (Oxford). 2005;44:7-16.
11. Clements K. M., Ball A. D., Jones H. B. Osteoarthritis Cartilage. 2009;17(6):805-812.

Keywords: COPD, osteoarthritis, cellular immunity