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https://doi.org/10.14300/mnnc.2016.11082

Role of gender in character of systemic and tissue abnormalities of hormonal homeostasis in rats with experimental model of lung metastasis

[Original research] [Experimental medicine]
Margarita Kozlova; Elena Frantsiyants; Lydia Trepitaki; Irina Kaplieva; Yulia Pogorelova; Gennadiy Sergostyants; Tamara Ayrapetova; Anna Chubaryan;

The role of hormones in the development of lung metastases (LM) is poorly studied. The purpose of the study was to analyze sex-dependent characteristics of dynamics of thyroid hormones, cortisol, TSH and ACTH in rats at early stages of LM experimental model. Levels of hormones were measured by radioimmunoassay in the blood, thyroid gland (TG) and adrenal glands (AG) of 48 white rats of both genders with ELM and in 20 intact animals on the 7 and 14 days after injection of sarcoma S-45 cells. It was determined that development of ELM up to the natural death of animals was 1.5 times longer in females compared to males; in females at the both stages it was accompanied by systemic hypercortisolemia with normalization of Т4-secreting function of TG by the 14th day, increased levels of bioactive Т3 and Т4 forms in the blood and restored concentration of free Т3 in TG. Males developed systemic hypocortisolemia and hyperthyroxinemia by the 14th day and showed decreased Т3 in TG and marked hypercortisolemia in AG with ACTH accumulation. The gender differences in neuroendocrine paraneoplastic abnormalities can play an important role in the rates of ELM development with its more rapid progression in male rats.

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Keywords: metastases, lungs, rats, hormones, gender differences