of the North Caucasus
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Carcinogenesis and violation of collagen
[CTD in adults]
Evgenia Kudinova;
The article presents the results of the study of the frequency and nature of malignancies of somatic and reproductive organs in 2813 blood relatives of 239 patients with disorders of collagen formation. For comparison, a similar analysis is conducted in 1467 blood relatives of 126 patients without violation of collagen formation. It is shown that the combination of carriage of protrombogenny DNA polymorphisms in women with impaired collagen formation and burdened thrombotic family history have high correlations with the frequency of malignancies in patients’ blood relatives. Thus, patients with impaired collagen formation and protrombogenny DNA-polymorphisms are at high risk group for the occurrence of cancer of reproductive and somatic organs.
References:
1. Aksel Ye. M., Davydov M. I. Statistika zabolevayemosti i smertnosti ot zlokachestvennykh novoobrazovany v 2000 godu. Sb. «Zlokachestvennye novoobrazovaniya v Rossii i stranakh SNG v 2000». M.: «RONTs im. N. N. Blokhina RAMN»; 2002. Р. 85-106.
2. Barkagan Z. S., Shilova A. N., Khodorenko S. A. Problemy gematologii i perelivaniya krovi. – Problems of Hematology and Blood Transfusion. 2002;2:52-59.
3. Barkagan Z. S., Momot A. P. Diagnostika i kontroliruyemaya terapiya narusheny gemostaza. M.: «NYuDIAMED»; 2008. 289 р.
4. Vlasov R., Sidorova I., Unanyan A. Vrach. – Doctor. 2011;2.
5. Gorbunova V. N., Baranov V. S. Vvedeniye v molekulyarnuyu diagnostiku i genoterapiyu nasledstvennykh zabolevany. SPb.: «Spetsialnaya literatura»; 1997. 287 р.
6. Gorbunova V. N., Imyanitov Ye. N. Genetika i kantserogenez. Uch. Posobiye. SPb; 2007. 57 р.
7. Kovalenko T. F., Vanyusheva O. V., Shilov I. A., Sosin D. V. Bioorganich. khimiya. – Bioorganic Chemistry. 2006;32(4):414-423.
8. Kudinova Ye. G., Uvarova Ye. V. Reproduktivnoye zdorovye detey i podrostkov. – Reproductive health of children and adolescents. 2011;4:15-22.
9. Sukhanova G. A., Barkagan Z. S., Kotovshchikova Ye. F. Gematologiya i transfuziologiya. – Hematology and Blood Transfusion. 2003;6:13-14.
10. Khodorenko S. A. Vestnik Rossyskogo onkologicheskogo nauchnogo tsentra imeni N. N. Blokhina RAMN. – Bulletin of the Russian Cancer Research Center named after NN Blokhin. 2008;19(2):69-71.
11. Baron J., Gridley G., Weiderpass E., Nyren G., Linet M. Lancet. 1998;351:1077-1080.
12. Вoccaccio C., Sabatino G., Medico E. Nature. 2005;434:396-400.
13. Gemma S. M. Haematologica. 1999;84(9):824-828.
14. Kakkar A., Levine M., Pinedo H. The oncologist. 2003;8:381-388.
15. Murchison J., Wyle L., Stockton D. Br. J. Cancer. 2004;91:92-95.
16. Prandoni P., Falanga A., Piccioli A. Lancet Oncol. In press. 2003;362:523-526.
Keywords: collagen formation disorders, malignant neoplasm, protrombogenny DNA polymorphisms
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy