of the North Caucasus
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On the mechanisms of progression of congenital developmental anomalies of urinari organs on the background of connective tissue displasia
[CTD in pediatrics]
Aneta Mambetova; Alla Inarokova; Nina Shabalova; Suleya Barazbieva;
The effect of connective tissue dysplasia (CTD) severity on the production of renin and aldosterone and also on occurrence of secondary complications of urinary system (US) congenital malformations (CM) was evaluated in 173 patients aged 3–18 years. Renin and aldosterone plasma levels were detected by ELISA. Significantly higher concentrations of renin, aldosterone and occurrence of secondary complications (nephrosclerosis, arterial hypertension (AH), reduced functional capacity of kidneys) were revealed in patients with moderate/severe CTD. The overproduction of renin and aldosterone was strongly associated with nephrosclerosis and АН. Thus, moderate/severe CTD in patients with CM of urinary system were associated with comparatively higher plasma concentrations of renin and aldosterone, development of nephrosclerosis and AH.
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Keywords: urinary system, malformations, connective tissue dysplasia, renin, aldosterone
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy