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Neurotoxicity caused by anesthetics in pediatric anesthesia

[Reviews]
Leo Booij;

In a review of the current literature assesses the recently discovered phenomenon and the toxicity of anesthetics in the developing child brain. The ways of diagnostics of morphological and functional abnormalities of brain activity in children. Provides indisputable data on the possibility of this type of interactions taking into account the mechanism of action of anesthetics. Comparative characteristics of strength toxic effects on children’s brain different types of inhalation and non-inhalation anesthetics. There is a comparison of the degree of toxic impact on the brain at single and repeated exposure of anesthesia. Emphasizes the lack of information and especially objective data visualization of degenerative changes in children’s brain due to ethical constraints and the impossibility of obtaining samples for biopsy. The conclusion about the appropriateness of expectant surgical tactics in the absence of urgent indications for surgical intervention to 4 years of a child’s life. Also, our patients need more researches in this direction.

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References:
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Keywords: anesthesia, newborns, children, pediatric surgery, neurotoxicity, neurodegeneration, cognitive disorders


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