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EBSCO

https://doi.org/10.14300/mnnc.2016.11011

Interaction niosomal doxorubicin cell membranes

[Pharmacology]
Igor Bazikov; Alexander Maltsev; Elena Diskaeva; Vera Lukinova; Safiyat Aytekova;

Study of change in the physical and structural properties of the membranes in contact with niosomal form of doxorubicin showed that the incorporation of niosomes increases membrane fluidity. As a result, they are becoming more permeable to water and other small hydrophilic molecules, increasing the speed of lateral diffusion of integral proteins. This increases the speed of transport, including the drugs through cell membranes, which in our opinion, is one of the mechanisms to increase the efficiency of therapeutic action of niosomal form of doxorubicin.

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References:
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Keywords: doxorubicin, niosomes, membranes