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[Pharmacology]
Stanislav Naumov; Ksenia Lomonosova; Eduard Arushanyan;
In the experimental model of rheumatoid arthritis it was determined that in the blood of rats with remote epiphysis, compared to falsely operated animals, plasma melatonin content falls, the level of cortisol increases and indicators of inflammation increase. At the same time, inflammatory activity of prednisolone and diclofenac changes. The outside introduction of the drug of melatonin is accompanied by a limitation of humoral parameters of inflammation.
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Keywords: arthritis, pinealectomy, melatonin, anti-inflammatory drugs