of the North Caucasus
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The role of HLA -polymorphism in resistance to the development of urological pathology in children of Kiro v region of Russia Federation
[Pediatrics]
Maxim Razin; Galina Zaitseva; Nikolai Suhih;
143 children of Russian ethnic group aged 5 – 15 years with various forms of congenital obstructive uropathy were observed. All patients underwent standard urological and immunogenetic examination to determine the factors of resistance to the development of pathology. In the study it was found that resistance to the development of congenital obstructive uropathies presents in individuals with HLA-alleles DRB1*07, DRB1*15 (2), DQB1*0302; phenotypes A1, A9; A9, A11 and haplotype combinations A3, B7; A11, B35; A19, B27. Congenital resistance to the development of secondary pyelonephritis was in individuals with HLAantigens DRB1*07, DRB1*09, DRB1*15 (2); phenotype A9, A11 and haplotype combinations A2, B12; A3, B7; A11, B35. Protective role in the development of congenital hydronephrosis in individuals was played by a specificities of HLA-system A11 and DQB1*0302; phenotypic combinations A2, A9; A9, A11 and haplotypes A2, B7; A2, B12. Resistance to the presence of pyeloectasia (minor anomalies of the urinary tract) was in individuals with alleles HLA DRB1*01, DRB1*11 (5) and haplotype combination of antigens A3, B7.
References:
1. Isakov Ju. F., Dronova A. F. Detskaja hirurgija. Nacional’noe rukovodstvo. M.: «GEOTAR-Media»; 2009. 1168 p.
2. Minaev S. V., Pavlenko I. V., Chumakov P. I., Timofeev S. I., Evsevyeva M. E. Medicinskij Vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2014;9 (3):273-274.
3. Razin M. P. Vrozhdennye obstruktivnye uropatii i vtorichnyj pielonefrit u detej (klinicheskie projavlenija, immunogeneticheskie parametry, immunnye narushenija i ih korrekcija): Autoref. dis. ... d-ra med. nauk. Kirov; 2007. 48 p.
4. Razin M. P. Vrozhdennye obstrukcii mochevogo trakta (uropatogenez, klinika, diagnostika i lechenie). Saarbrücken, Deutschland:«LAMBERT Academic Publishing»; 2013. 184 p.
5. Razin M. P., Galkin N. K., Suhih V. N. Detskaja urologija- andrologija: Uchebnoe posobie. M.:«GEOTAR-Media»; 2011. 128 p.
6. Razin M. P., Zajceva G. A., Illek Ja.Ju. Urologija. – Urology. 2007;2:71-76.
7. Razin M. P., Zajceva G. A., Illek Ja. Ju., Baturov M. A. Vjatskij medicinskij vestnik. – Medical newsletter of Vyatka. 2012;1:31-35.
8. Razin M. P., Illek Ja. Ju., Zajceva G. A., Galkin V. N., Skobelev V. A. Detskaja hirurgija. – Pediatric surgery. 2003;1:20-22.
9. Razin M. P., Illek Ja. Ju., Zajceva G. A., Razin A P. Fundamental’nye issledovanija. – The fundamental researches. 2005;6:103-104.
10. Suhih N. K., Razin M. P. Detskaja hirurgija. – Pediatric surgery. 2004;4:46-47.
11. Razin M. P., Zykova I. V., Razin A. P., Makhneva V. A. Eur. J. Nat. Hyst. 2009;5:50-51.
12. Sweigaard A., Ryder L. P. Tissue Antigens. 1994;43:18-27.
Keywords: congenital obstructive uropathy, immunogenetics, children
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy