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https://doi.org/10.14300/mnnc.2015.10034

Specific features of peripheral blood lymphocytes immunophenotype in pregnant women with chronic periodontitis

[Obstetrios and gynecology]
Viktoria Prohodnaya;

Purpose of study was to identify the specific features of cellular immunity through immunophenotypic analysis of peripheral blood lymphocytes in pregnant women with inflammatory periodontal disease depending on the structure of the pathology as well as the severity of chronic periodontitis. 165 pregnant women with inflammatory periodontal disease; 31 pregnant women with physiological pregnancy; 32 healthy female volunteers. All the women had their immunophenotype of peripheral blood lymphocytes investigated. The immunophenotyping of the lymphocytes bearing the CD3+, CD4+, CD8+, CD16+, and CD95+ markers was performed with laser flow cytometry. the study showed that along with an increasing degree of chronic periodontitis severity the pregnant women developed more pronounced lymphopenia, imbalance in T cell subsets with a decrease in the relative number of mature T-lymphocytes and T-helper cells against an increasing number of cells possessing killer and apoptotic activity. the pregnant women with chronic periodontitis revealed changes in the lymphocytes immunophenotype, which were basically similar to alterations in pregnancies with no dental pathologies, yet proved more prominent, which predisposed to a prolonged course of chronic inflammatory diseases.

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Keywords: pregnancy, chronic periodontitis, lymphocytes immunophenotype, cellular immunity