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https://doi.org/10.14300/mnnc.2015.10014

Positive impact of melatonin and phenazepam combination on behavioral activity of rats

[Clinical Pharmacology]
Eduard Arushanyan; Eduard Beyer; Olga Kaminskaya; Ludmila Sotnikova;

The effect of melatonin (0,05, 0,1 and 5 mg/kg), phenazepam (0,05, 0,1 and 2 mg/kg) and their combination on behavior of rats were studied in the «open field» test, elevated maze and extrapolational deliverance. In the case of combined application, melatonin optimized anxiolytic activity of phenazepam and limited its negative impact on memory and locomotion of animals. The results of the study suggest that combined application of melatonin and phenazepam in clinical practice is perspective.

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References:
1. Arushanyan E. B. Eksper. i klin. farmakol. – Experimental and Clinical Pharmacology. 2012;75(3):35-40.
2. Arushanyan E. B., Popov A. V. Eksper. i klin. farmakol. – Experimental and Clinical Pharmacology. 2013;76(4):15-17.
3. Voronina T. A., Ostrovskaya R. U. Metodicheskiye ukazaniya po izucheniyu psikhotropnoy aktivnosti farmakologicheskih sredstv. M.; 2000. 153-158 р.

Keywords: melatonin, phenazepam, combined application