• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2014.09074

The mechanisms of endothelial function infringement in rats with toxic angiopathy and its possible pathogenetic correction

[Experimental medicine]
Sergey Dzugkoev; Irina Mozhayeva; Larisa Gigolaeva; Angelica Tedtoeva; Elena Takoeva; Olga Marghiev; Mikhail Otiev; Fira Dzugkoeva;

The aim of the research was to investigate the effects of the endogenous antioxidants on the background of cobalt chloride intoxication on biochemical indicators of endothelial dysfunction and microcirculation hemodynamics in rats in chronic experiment. The indicators of LPO, AOS, the content of nitric oxide, the exchange of cholesterol and hemodynamics in the microvasculature were researched. The data showed that on the background of treatment with coenzyme Q10 and its combination with L arginine free radical oxidation was oppressed, activity of enzymes of AOD – SOD and concentration of total metabolites of nitric oxide were increased. At the same time the content of total cholesterol and LDL cholesterol was reduced, HDL cholesterol increases. This helps in bioavailability of NO. These positive biochemical changes were reflected in increased speed of hemodynamics and microcirculation.

Download

References:
1. Bondarenko L.V. Ekologicheskaya genetika. – Ecological Genetics. 2007;5(1):39-41.
2. Burdin N. V., Grebennikova V. V., Lebedev V. I., Mongush A.A., Burdin V. N. Uspekhi sovremennogo estestvoznaniya. – Success of modern natural science. 2008;7:64.
3. Vanin A. F. Vestnik RAMN. – Bulletin of Medical Sciences. 2000;4:3-10.
4. Dzugkoyev S. G., Metelskaya V. A., Dzugkoyeva F. S. Kardiovaskulyarnaya terapiya i profilaktika. – Cardiovascular Therapy and Prevention. 2010;8:63-68.
5. Kamyshnikov V. S. Opredeleniye soderzhaniya (aktivnosti) tseruloplazmina. Spravochnik po kliniko-biokhimicheskoy laboratornoy diagnostike. Minsk;2003;2:71-79.
6. Korolyuk M. A., Ivanova L. I., Mayorova I. G. Laboratornoye delo. – Laboratory work. 1988;1:16-19.
7. Metelskaya V. A., Gumanova N. G. Laboratornaya meditsina. – Laboratory Medicine. 2005;7:19-24.
8. Okhrimenko S. M., Guryeva N. Yu., Kaliman P. A. Vestnik Kharkovskogo natsionalnogo universiteta im. V. N. Karazina. Seriya: biologiya. – Bulletin of Kharkov National University. VN Karazina. Series: Biology. 2005;1-2:56-60.
9. Asakawa T., Matsushita S. Lipids. 1980;15:137-140.
10. Chin J. H., Azhar S., Hoffman B. B. Jnvest. 1982;89:10-18.
11. Plane F., Bruckdorber K. R., Kerr P. et al. Br.J. Pharmacol. 1992;105:216-222.
12. Zulli A., Widdop B., Hare D. L. et al. Arterioscler. Thromb. vasc. Biol. 2003;23:1358-1363.

Keywords: cobalt chloride, lipid peroxidation, AOD, nitric oxide, coenzyme Q10, endothelial dysfunction