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https://doi.org/10.14300/mnnc.2014.09072

Study adaptogenic effect of suppositories comprising glutamic acid and a propolis extract

[Pharmacology]
Elena Simonyan; Julia Shikova;

The experimental and theoretical justification of suppositories containing glutamic acid and propolis extract and study of its adaptogenic effect was performed. To select the optimal composition of suppository we have studied hydrophilic, lipophilic and amphiphilic base and added the excipients. Detection of bioavailability was carried out by the diffusion in the agar gel and dialysis through a semipermeable membrane. Acute hypoxia with hypercapnia in mice was induced by placing each animal in the pharmacy shtanglas of clear glass 250 ml in volume and with friction lid. Acute hypobaric hypoxia was induced in the electric-furnace by «raising» animals on the «height» of 10,000 m with an average speed of 50 m/sec. Rectal and oral administration of the glutamic acid has increased the life expectancy in the animals of the main group compared to controls. Survival of animals in acute hyperbaric hypoxia significantly increased in comparison with the control group treated by isotonic sodium chloride solution.

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Keywords: hypoxia, hypercapnia, glutamic acid, propolis, suppositories