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https://doi.org/10.14300/mnnc.2014.09032

The prognostic value of bactericidal/ permeability-increasing protein in infants with congenital pathology of the gastrointestinal tract

[Original research] [Surgery]
Sergey Minaev; Alesya Isaeva; Elena Tovkan; Chersi Gudiev; Sergey Timofeev; Alexandr Kachanov; Nadezhda Romaneeva;

The aim of this study was to investigate the influence of bactericidal/permeability-increasing protein (BPI) on the development of complications after abdominal surgery in infants

We investigated the intestinal hormone levels in the blood before and after surgery (1, 3, 7 and 14 postoperative days) in 24 infants with congenital intestinal obstruction anomaly and atresia. The children were divided into group 1 (N=10), which included newborns with inflammatory complications after the surgery, and group 2 (N=14), which included newborns without inflammatory complications. Twenty infants without operative treatment formed the control group. The level of BPI was determined by ELISA.

The level of BPI before surgery in group 2 was significantly higher than that in group 1 (10.5 ng/ml (3.35–19.05) and 3.33 ng/ml (2.74–4.51) p<0.05, respectively). In a group data comparison, BPI was significantly higher in group 1, even on the third day after surgery (2.915 ng/ml (1.37–55.5) and 15.75 ng/ml (3.32–50.5) p<0.05, respectively). The data showed values of BPI in the group of patients with inflammatory complications that were higher than those in the main and comparison groups from the third postoperative day.

The increased BPI in the blood on the first post- operative day in newborns was a good prognostic sign. An initial low-level BPI and the increased BPI in the blood on the third postoperative day in newborns was a poor prognostic sign and was evidence of development of inflammatory complications.

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Keywords: astrointestinal tract, congenital anomaly, infants, bactericidal/permeability-in- creasing protein