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https://doi.org/10.14300/mnnc.2023.18002

Features of cardiac remodeling in patients with frequent exacerbations of severe COPD and in its combination with arterial hypertension

[Original research] [Internal diseases]
Anna Yuryevna Ryabova; Irina Kozlova; Tatiana Germanovna Shapovalova; Mikhailovna Shashina Marina; Anastasia Sergeevna Shiryaeva;

Determination of ultrasound markers of cardiac remodeling in patients with severe chronic obstructive pulmonary disease (COPD) was provided, taking into account the characteristics of its course and comorbidity in arterial hypertension (AH). 114 patients with severe COPD were examined divided into 4 groups, taking into account the frequency of exacerbations, the presence of hypertension. The structure and functions of the heart chambers were assessed by echocardiography.

Frequent exacerbations during the year in isolated severe COPD contribute to the development of concentric remodeling of the left ventricle. Comorbid hypertension in these patients is associated with the development of concentric LV myocardial hypertrophy. In COPD with frequent exacerbations, and comorbid hypertension, violations of systolic and diastolic functions of the left ventricle were the most pronounced.

An increased level of myocardial stress can be considered as an additional marker of left ventricular remodeling in severe COPD with frequent exacerbations.

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Keywords: severe chronic obstructive pulmonary disease, frequent exacerbations, arterial hypertension, cardiac remodeling, myocardial stress